Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination

Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial

BACKGROUND Vaccine development for influenza A/H5N1 is an important public health priority, but H5N1 vaccines are less immunogenic than seasonal influenza vaccines. Adjuvant System 03 (AS03) markedly enhances immune responses to H5N1 vaccine antigens, but the underlying molecular mechanisms are incompletely understood. OBJECTIVE AND METHODS We compared the safety (primary endpoint), immunogen...

Immune Activation and Antigen Presentation

Matthew D. Griffin1, Nianzeng Xing1,3, and Rajiv Kumar1,2 1Department of Internal Medicine, Division of Nephrology, and 2Department of Biochemistry and Molecular Biology and Mayo Proteomics Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905; email: [email protected]; [email protected]; [email protected] 3Current address: Department of Urology, Beijing Chao Yang Ho...

Simplex Virus Immune Evasion Dendritic Cells as a Target for Herpes CD1 Antigen Presentation by Human

Immunogenicity Profile of a 3.75-μg Hemagglutinin Pandemic rH5N1 Split Virion AS03A-Adjuvanted Vaccine in Elderly Persons: A Randomized Trial

BACKGROUND Elderly persons often experience a reduced immune response to influenza vaccination. We evaluated the usual dose of AS03(A)-adjuvanted H5N1 pandemic vaccine (3.75 μg hemagglutinin of A/Vietnam/1194/2004-like strain) compared with a double dose in an elderly population. METHODS This phase 2, open-label study (NCT00397215; http://www.clinicaltrials.gov) randomized participants (age, ...

Tracing Functional Antigen-Specific CCR6+ Th17 Cells after Vaccination

BACKGROUND The function of T helper cell subsets in vivo depends on their location, and one hallmark of T cell differentiation is the sequential regulation of migration-inducing chemokine receptor expression. CC-chemokine receptor 6 (CCR6) is a trait of tissue-homing effector T cells and has recently been described as a receptor on T helper type 17 (Th17) cells. Th17 cells are associated with a...